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Camptothecin hl-60

WebAug 15, 2024 · The IC 50 values on the HL60 cells are comparable to SN38 and 9-N - (2′-hydroxyethyl)methyl substituted compound 2b. Table 1. IC 50 values of Irinotecan (1c), SN38 (1d) and SN38 derivatives 2a-j. nontoxic - lack of cell viability decrease/toxicity in the studied compound concentration range. WebFeb 1, 2008 · In the present study, we investigated the role of recombinant human phospholipase D2 (rhPLD2) on proliferation and apoptosis in human leukemia HL‐60 cells which induced by camptothecin. Our research demonstrated that various concentrations of rhPLD2 inhibit the growth of HL‐60 cells in a dose‐dependent manner, and rhPLD2 plus …

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WebNational Center for Biotechnology Information WebFeb 1, 2008 · So, we conclude that rhPLD2 alone cannot induce apoptosis in HL-60 cells, but it can potentiate the apoptosis of HL-60 cells induced by camptothecin. Similarly, we show that both rhPLD2 and standard PLD were able to enhance camptothecin-induced apoptosis of HL-60 cells. Previousarticlein issue Nextarticlein issue Keywords rhPLD2 … dominic robson tlt https://chriscroy.com

Camptothecin - an overview ScienceDirect Topics

WebCamptothecin, a cytotoxic plant alkaloid with antitumor properties, is a prototypic DNA topoisomerase I inhibitor. ... This camptothecin concentration range works well for inducing Jurkat or HL 60 cell suspensions which usually run in the 1 x 105 – 1 x 106 cell/mL concentration range. At this concentration range successful apoptosis induction ... WebOct 1, 2003 · (A) HL-60 cells were treated with 2 μM camptothecin only or in the presence of 20 μM calpeptin (calpain inhibitor), or 20 μM cathepsin inhibitor I (CI) or 20 μM ALLM (inhibits calpain and cathepsin) for the indicated times. (B) HL-60 cells were treated with 20 μM cisplatin, or 50 μM etoposide or 0.5 μg/mL adriamycin alone for 20 hours or ... WebThe Aerospace Maintenance Competition is an annual celebration of aviation maintenance technicians and their skills. Held during Aviation Week at the MRO Ame... dominic reeds md

Apoptosis and Its Modulation in Human Promyelocytic HL …

Category:Camptothecin - an overview ScienceDirect Topics

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Camptothecin hl-60

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WebHeli continuously extends its best products and service to global market through regional centers and distributors networks. WebJun 1, 1992 · Camptothecin or teniposide induced apoptosis selectively in S phase of HL-60 cells; apoptotic cells from camptothecin-treated cultures, however, despite the marked nucleolysis, still expressed p120.

Camptothecin hl-60

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WebAug 26, 2002 · Camptothecin (CAM; Sigma, St. Louis, MO) initiates apoptosis in the human promyelocytic leukemia cell line, HL-60, via its binding to topoisomerase I–DNA … Web周 珏，卢林明，张根葆(皖南医学院 1.病理解剖学教研室;2.病理生理学教研室;3.蛇毒研究所，安徽 芜湖 241002)蛇毒具有广泛的生

WebNov 1, 2002 · The role of mitochondria in HL-60 apoptosis was explored using an inhibitor of oxidative phosphorylation, antimycin A (AMA). Methods: Changes in cell light scatter, … WebThis potent antioxidant is a cytoprotectant in several experimental models. However, its neuroprotective activities are scarcely available, especially in the hippocampal region associated with...

WebAug 1, 1999 · HL-60 human promyelocytic leukemia cells were cultured in RPMI 1640 supplemented with 10% fetal bovine serum. For induction of apoptosis, cells were exposed for 3 h to 0.1 μg/ml DNA topoisomerase I inhibitor, camptothecin. Quantitative analysis of apoptosis was carried out by flow cytometry. WebCamptothecin is a plant alkaloid present in wood, bark, and fruit of the Asian tree Camptotheca acuminata. From a shaky beginning complicated by toxic effects and logistical issues, camptothecin derivatives have advanced to become standard components in the treatment of several malignancies.

WebJan 15, 2024 · In summary, 12 novel biotinylated camptothecin derivatives were designed, synthesized, and evaluated for anticancer activities against a panel of five human cancer …

WebCamptothecin is an alkaloid first isolated from the stem wood of the tree Camptotheca acuminata (Nyssaceae), and has potent antitumor activity. 31 Camptothecin acts by … dominic refrigerators for rvWebNov 5, 2015 · The effect of vincristine, cisplatin or 10-hydroxy camptothecin on inducing apoptosis of HL-60 cells co-cultured with the MS-5 cell layer within 48 h was tested with/without E5. dominic reitmayer architektWebDNA single- strand breaks were detected using alkaline sucrose gradient centrifugation when HL-60 cells were incubated with 10 μMCPT or 10 μMSN-38 for 30 min. These … dominic real world 2WebThere have been some conflicting results concerning whether annexin V binds to camptothecin (CAM)-treated HL-60 cells, a commonly used model for apoptosis. We investigated the effects of culturing HL-60 cells for up to 8 h with a range of CAM concentrations. METHODS We used flow cytometry to measure cellular light scatter, … city of atlanta boundary tree agreementWeb14808-60-7 Wt. % 60 - 100 1 - 5 This product is a hazardous chemical as defined by the OSHA Hazard Communication Standard, 29 CFR 1910.1200. Gypsum (calcium sulfate) … city of atlanta boil water advisory mapWebJun 29, 2015 · ；D. 大黄素无法捕获Topo I-DNA 的可切割复合物，Topo 的抑制剂CPT作为阳性对照； 大黄素能够诱导稳定的TopoII α-DNA 可切割 复合物，Topo II 的抑制剂VP16 作为阳性对照。G. 用大黄素处理HL-60 和HL-60/MX2 细胞后，检测γ -H2AX 的表达。H. 大黄素和VP16在Topo II –缺陷型细胞HL ... city of atlanta building department permitsWebWe investigated expression of cyclin A in HL-60 cells after induction of apoptosis with doxorubicin and etoposide. Following apoptotic trigger, both cells arrested in G2/M phase of the cell cycle... city of atlanta budget book