Cardiolipin externalization of mitochondria
WebMar 6, 2024 · Mitochondrial energy production is essential for normal brain function. Traumatic brain injury (TBI) increases brain energy demands, results in the activation of … WebFeb 26, 2024 · Cardiolipin is an anionic phospholipid whose externalization has been shown to dramatically lower the surface charge of the mitochondria 26. To assess …
Cardiolipin externalization of mitochondria
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Web1. Structure and Composition. Cardiolipin is the trivial but universally used name for a lipid that might be better termed 'diphosphatidylglycerol' or more precisely 1,3‑bis(sn‑3'-phosphatidyl)-sn-glycerol.It is a unique phospholipid with what might be considered to be a dimeric structure by comparison with other phospholipids, having four acyl groups, five … WebJan 8, 2016 · Externalization of the inner mitochondrial membrane phospholipid, cardiolipin (CL), to the surface of the outer mitochondrial membrane (OMM) was identified as a mitophageal signal...
WebApr 20, 2014 · Cardiolipin (CL) is a unique phospholipid that is almost exclusively localized at the level of the inner mitochondrial membrane (IMM), where it is biosynthesized. This … WebMar 21, 2024 · Our findings uncover the critical role of Sam50 in maintaining mitochondrial membrane integrity and mtDNA stability in hepatocytes and reveal that Sam50 depletion–induced cardiolipin externalization is a signal of mtDNA release and controls mtDNA-dependent innate immunity. CONFLICT OF INTEREST Nothing to report. Citing …
WebMyocardial ischemia-reperfusion (I/R) injury always occur during the recovery of myocardial blood supply with high morbidity and mortality. Although, various therapeutic schedules were applied in clinic, there are real problems that have to be resolved on curative effect. WebSep 15, 2013 · Cardiolipin is an inner mitochondrial membrane phospholipid. We found that rotenone, staurosporine, 6-hydroxydopamine and other pro-mitophagy stimuli caused externalization of cardiolipin...
WebCardiolipin is a unique phospholipid, which is almost exclusively localized in the mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. After primary synthesis, the mature acyl chain composition of cardiolipin is achieved by at least …
WebExternalization of the phospholipid cardiolipin (CL) to the outer mitochondrial membrane has been proposed to act as a mitophagy trigger. CL would act as a signal for binding … qualities of wonder womanWebIn healthy mitochondria, cardiolipin is found almost exclusively in the MIM, where it helps to stabilize cristae and support the assembly and function of electron transport chain complexes ... Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat. Cell Biol. 2013; 15 ... qualities of work ethicWebJan 24, 2010 · PINK1 kinase activity and its mitochondrial localization sequence are prerequisites to induce translocation of the E3 ligase Parkin to depolarized mitochondria. Subsequently, Parkin mediates the ... qualities of the tongueWebApr 1, 2024 · Cardiolipin (CL) is a mitochondria-exclusive phospholipid essential for mitochondrial morphology, bioenergetics, dynamics, and signaling pathways. ... Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. qualities of yogi adityanathWebJun 11, 2024 · Furthermore, as the externalization of cardiolipin to the outer mitochondrial membrane is a mitophagy signal, it would be interesting to observe the distribution of cardiolipin in donut and swollen mitochondria. LC3 contains cardiolipin-binding sites, which is important for the engulfment of mitochondria by the autophagic … qualities of working in a teamWebCT Chu, J Ji, RK Dagda, JF Jiang, YY Tyurina, AA Kapralov, VA Tyurin, N Yanamala, IH Shrivastava, D Mohammadyani, KZQ Wang, J Zhu, J Klein-Seetharaman, K Balasubramanian, AA Amoscato, G Borisenko, Z Huang, AM Gusdon, A Cheikhi, EK Steer, R Wang, C Baty, S Watkins, I Bahar, H Bayır & VE Kagan (2013) Cardiolipin … qualities people want out of entertainmentWebCardiolipin (CL) is a mitochondria-exclusive phospholipid essential for mitochondrial morphology, bioenergetics, dynamics, and signaling pathways. Alterations in brain CL are associated with impaired neuronal function and neurodegeneration. qualities required for blackbox tester