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Hepatic asialoglycoprotein receptor

The asialoglycoprotein receptors (ASGPR) are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are integral membrane proteins and are located on mammalian hepatocytes (liver cells), … Meer weergeven The asialoglycoprotein receptor was first characterized in 1968 by Morell et al. and was the first mammalian lectin identified. The researchers transferred radioactively-labeled ceruloplasmin that had undergone a reaction … Meer weergeven • Asialoglycoprotein+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Meer weergeven Asialoglycoprotein receptors function to catabolize galactosyl and N-acetylgalactosaminyl-containing substrates. More specifically, in most mammals, … Meer weergeven The human asialoglycoprotein receptors composed of two units, H1 and H2. Each of these units have their N-terminus within the cytoplasm of a liver cell, and a carbohydrate recognition domain (CRD) on the extracellular side. The CRD functions to … Meer weergeven Webto the human hepatic asialoglycoprotein receptor did not require the lectinlike activity of the asialoglyco- protein receptor. Thus the human hepatic asialoglyco- protein receptor …

The Hepatic Asialoglycoprotein Receptor Regulates Platelet …

Web10 apr. 2015 · The asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally on extra-hepatic cells. This makes it specifically attractive for receptor-mediated drug delivery with minimum concerns of toxicity. ASGPR facilitates internalization by clathrin-mediated endocytosis and exhibits high affinity for … Web17 jul. 2024 · Desialylated platelets are reportedly cleared by hepatocytes via the hepatic asialoglycoprotein receptor (ASGPR) (also called the Ashwell–Morell receptor (AMR); … map liberty sc https://chriscroy.com

The asialoglycoprotein receptor: relationships between structure ...

WebThe asialoglycoprotein receptor antibody (ASGPR)—a type II transmembrane glycoprotein also known as hepatic lectin—is the only liver-specific autoantigen to be … Web8 sep. 2024 · Willoughby and colleagues show that GalNAc-siRNA conjugate uptake is specifically mediated through the hepatic expressed asialoglycoprotein receptor and that potent conjugates are capable of robust gene silencing in reduced receptor settings. These data combined support the therapeutic potential in disease(s) where receptor levels may … Web1 nov. 1994 · The Asialoglycoprotein Receptor Mediates Hepatic Binding and Uptake of Natural Hepatitis B Virus Particles Derived From Viraemic Carriers Microbiology Society Volume 75, Issue 11 Research Article Free The Asialoglycoprotein Receptor Mediates Hepatic Binding and Uptake of Natural Hepatitis B Virus Particles Derived From … kris mayes attorney general arizona

Asialoglycoprotein receptor - Wikipedia

Category:Hepatic asialoglycoprotein receptor‐mediated binding of human

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Hepatic asialoglycoprotein receptor

Specific capture of glycosylated graphene oxide by an ...

WebThe hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the endocytosis/lysosomal degradation of desialylated glycoproteins following … Web10 jun. 2024 · Trivalent N-acetyl-D-galactosamine (GalNAc) is known to be a high-affinity exogenous ligand against the asialoglycoprotein receptor (ASGPR), which is highly expressed on hepatocytes. In this study, we report that the kinetics of the hepatic uptake process between the two types of targeting pathways are different.

Hepatic asialoglycoprotein receptor

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WebIn mammals, clearance of desialylated serum glycoproteins to the liver is mediated by a galactose-specific hepatic lectin, the 'asialoglycoprotein receptor'. In humans, serum glycoprotein glycans are usually capped with sialic acid, which protects these proteins against hepatic uptake. However, in m … Web购买Abcam人Asialoglycoprotein Receptor 1/HL-1多肽(ab98248)，提供28,000 ... Expressed exclusively in hepatic parenchymal cells.

WebThe asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The …

WebEndocytosis and function of the hepatic asialoglycoprotein receptor Subcell Biochem. 1993;19:125-61. doi: 10.1007/978-1-4615-3026-8_5. Author P H Weigel 1 Affiliation 1 … WebAs a putative mechanism of hepatitis B virus (HBV) uptake into hepatocytes the interaction between HBV and the hepatic, human-derived asialoglycoprotein receptor …

Web20 jan. 2000 · The human asialoglycoprotein receptor (ASGPR), also called hepatic lectin, is an integral membrane protein and is responsible for the clearance of desialylated, galactose-terminal glycoproteins from the circulation by receptor-mediated endocytosis.

WebRat dimeric IgA does not compete for this binding site. We conclude that human IgA can compete with ligands for the asialoglycoprotein receptor of rat, monkey and human liver. This receptor may provide an alternative pathway for the hepatic processing of IgA and IgA immune complexes when secretory component-mediated uptake is not available as ... maplibre fitboundsWeb25 dec. 2001 · The role of the asialoglycoprotein receptor in clearance was studied by preinjection (at 1 min before injection of the radiolabel) of 50 mg·kg −1 body weight of asialo-fetuin (a blocker of the asialoglycoprotein receptor). Injection of α3-galactosylated α 1 -AGP was done in duplicate, that of asialo-α 1 -AGP in triplicate. map liberty islandWebThis receptor may provide an alternative pathway for the hepatic processing of IgA and IgA immune complexes when secretory component-mediated uptake is not available as in … map liberty township ohioWeb10 apr. 2024 · Acid-degradable polyrotaxanes (PRXs) containing threading β-cyclodextrins (β-CDs) are promising candidates for therapeutic applications of β-CDs in metabolic diseases with cholesterol overload or imbalance. To improve cellular uptake specificity and efficiency of PRXs in hepatocytes, N-acetyl-d-galactosamine (GalNAc)-modified PRXs … map liberty new yorkWeb20 apr. 2001 · The asialoglycoprotein receptor (ASGPR) 1 was originally identified by Ashwell and Morell as a hepatic receptor that mediates the rapid clearance of serum glycoproteins containing terminal galactose residues … kris mcarthur real estateWebThe asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the … map life sciences limitedWeb12 apr. 2024 · Journal Pre-proof Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism Gabriel Chalhoub, Alina Jamnik, Laura Pajed, Stephanie Kolleritsch, Victoria Hois, Antonia Bagaric, Dominik Prem, Anna Tilp, Dagmar Kolb, Heimo Wolinski, Ulrike … kris mcarthur king county