WebSingle cell sequencing of neutrophils demonstrates phenotypic heterogeneity and functional plasticity in health, disease, and cancer Alistair S. McLaren, Rana Fetit, Colin S. Wood, John Falconer, Colin W. Steele WebphenoData returns an object containing information on both variable values and variable meta-data. varLabels returns a character vector of measured variables. pData returns a data frame with samples as rows, variables as columns. varMetadata returns a data frame with variable names as rows, description tags (e.g., unit of measurement) as columns. …

Phenotypic screens as a renewed approach for drug discovery

Phenotypic variation (due to underlying heritable genetic variation) is a fundamental prerequisite for evolution by natural selection. It is the living organism as a whole that contributes (or not) to the next generation, so natural selection affects the genetic structure of a population indirectly via the contribution … Zobraziť viac In genetics, the phenotype (from Ancient Greek φαίνω (phaínō) 'to appear, show, shine', and τύπος (túpos) 'mark, type') is the set of observable characteristics or traits of an organism. The term covers the organism's Zobraziť viac Despite its seemingly straightforward definition, the concept of the phenotype has hidden subtleties. It may seem that anything dependent on the genotype is a phenotype, including molecules such as RNA and proteins. Most molecules and structures coded … Zobraziť viac Although a phenotype is the ensemble of observable characteristics displayed by an organism, the word phenome is sometimes used to refer to a … Zobraziť viac The RNA world is the hypothesized pre-cellular stage in the evolutionary history of life on earth, in which self-replicating RNA molecules … Zobraziť viac Phenotypes are determined by an interaction of genes and the environment, but the mechanism for each gene and phenotype is different. For instance, an albino phenotype … Zobraziť viac Large-scale genetic screens can identify the genes or mutations that affect the phenotype of an organism. Analyzing the phenotypes of … Zobraziť viac • Ecotype • Endophenotype • Genotype-phenotype distinction • Molecular phenotyping Zobraziť viac WebThe skin's most important function is to act as a barrier against fluid loss, microorganism infections, and percutaneous absorption. To fulfill this role, keratinocytes proliferate and … sql find mode of data

The genetics of phenotypic plasticity in livestock in the era of ...

Web1. dec 2000 · The phenotypic response pattern of a given genotype is its ‘norm of reaction’, a term coined by German geneticists at the start of the 20th century. Later researchers typically studied genotypes in a single, standardized laboratory environment, essentially measuring one phenotypic point along each genotype's norm. WebAn interdisciplinary scientist with extensive experience leading projects in the intersection of big data analytics, machine learning, drug discovery, and biotechnology ... WebEx vivo phenotyping of total T cells and HBV-specific T cell function were analysed as previously described (for antibodies see online supplemental materials and methods ). 19 Briefly, PBMCs were expanded for 10 days and stimulated with HBV-specific OLPs or HLA-A*02-restricted peptides. sql find oldest record